Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.
During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an green and gold masquerade mask accumulation of unfolded proteins in the endoplasmic reticulum (ER).To restore ER homeostasis, cells initiate the unfolded protein response (UPR) by activating